Abstract #5131

Non-Gaussian diffusion of human skeletal muscle water and metabolites observed using proton diffusion-weighted spectroscopy

David A. Reiter¹, Christopher Bergeron¹, Richard G. Spencer¹, Luigi Ferrucci¹, and Itamar Ronen²

¹National Institute on Aging, NIH, Baltimore, MD, United States, ²C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Micro- and ultrastructural properties of skeletal muscle have a direct impact on function and modulate the diffusion of both water and metabolites. Anomalous diffusion models can be used to characterize non-Gaussian diffusion and specifically subdiffusive dynamics, which are expected to reflect ultra-structural tissue properties. Here, we present fits of the single-parameter Mittag-Leffler diffusion model to diffusion weighted spectroscopy data, showing subdiffusive motions of skeletal muscle water and metabolites.

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