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Abstract #5131

Non-Gaussian diffusion of human skeletal muscle water and metabolites observed using proton diffusion-weighted spectroscopy

David A. Reiter1, Christopher Bergeron1, Richard G. Spencer1, Luigi Ferrucci1, and Itamar Ronen2

1National Institute on Aging, NIH, Baltimore, MD, United States, 2C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Micro- and ultrastructural properties of skeletal muscle have a direct impact on function and modulate the diffusion of both water and metabolites. Anomalous diffusion models can be used to characterize non-Gaussian diffusion and specifically subdiffusive dynamics, which are expected to reflect ultra-structural tissue properties. Here, we present fits of the single-parameter Mittag-Leffler diffusion model to diffusion weighted spectroscopy data, showing subdiffusive motions of skeletal muscle water and metabolites.

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