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Abstract #5137

Vertebral strength prediction in diabetic patients: quantification of bone marrow fat content obtained by IDEAL-IQ

Shinpei Yamaguchi1, Takatoshi Aoki1, Koichi Nakagami1, Masami Fujii1, Yoshiko Hayashida1, Yosuke Okada2, Yoshiya Tanaka2, and Yukunori Korogi1

1Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan, 2First department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

Although bone mineral density (BMD) by dual X-ray absorptiometry (DXA) has been used to predict bone strength, diabetes mellitus (DM) patients have an elevated fracture risk despite normal BMD. We evaluated the availability of the fat fraction (FF) using IDEAL-IQ for vertebral strength prediction in DM patients. The correlation between the failure load by CT-based finite-element method and the BMD with age and the FF using IDEAL-IQ was significantly higher than that between the failure load and the BMD alone (p<.001). FF using IDEAL-IQ in combination with BMD measurements can potentially be used in predicting bone strength in DM patients.

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