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Abstract #5139

Preliminary investigation: Gaussian and non-Gaussian measurements of water diffusion in diagnostic differentiation of focal lesions of malignant spinal bone tumors

Miyuki Takasu1, Yuji Akiyama1, Kazushi Yokomachi1, Yoko Kaichi1, Chihiro Tani1, Koichi Oshio2, and Kazuo Awai1

1Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, Japan, 2Diagnostic Radiology, Keio University School of Medicine, Japan

We compared the potential of various diffusion parameters obtained from Gaussian and non-Gaussian diffusion models in differentiating focal lesions of malignant spinal tumors. Mean signal intensity was calculated by placing ROIs within focal lesions for 9 b-values in each subject. ADC, frac<1, frac>3, and PG(D) differed significantly between focal lesions of myeloma and LCA. Frac>3 and PG(D) was significantly different between focal lesions of myeloma and MMK. Non-Gaussian diffusion parameters may provide additional information and improve the differentiation of malignant focal lesions compared with conventional diffusion parameters, which would be helpful in improving therapy strategies.

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