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Abstract #5146

Comparison of whole-body morphologic and functional MRI with automated "bone subtraction" CT-image analysis for monitoring of longitudinal spine involvement in patients with multiple myeloma

Marius Stefan Horger1, Sebastian Werner1, Wolfgang Thaiss2, and Christopher Kloth1

1Radiology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany, 2Radiology, Eberhard-Karls-Univesity Tuebingen, Tuebingen, Germany

Imaging diagnosis and therapy monitoring of multiple myeloma (MM) is challenging due to the combined bone and bone marrow involvement and at the same time often imperative due to possible failure of hematological markers (e.g. non-secretory myeloma). MRI is the most powerful MM-imaging technique for visualization of medullar involvement whereas CT optimally detects myeloma bone-disease (BMD). A new CT post-processing software (bone subtraction-BS) is generating subtraction (difference) maps of baseline and follow-up non-enhanced CT exams highlighting the course of BMD. Hence, the purpose of this study was to assess strengths and limitations of these two imaging modalities for longitudinal disease monitoring.

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