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Abstract #5152

Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters in Metastatic Bone Lesions of Non-small Cell Lung Cancer: Comparison between Lesions with and without Epidermal Growth Factor Receptor (EGFR) Mutation in Primary Cancer

Hyun Su Kim1 and Young Cheol Yoon1

1Radiology, Samsung medical center, Seoul, Korea, Republic of

The presence of the epidermal growth factor receptor (EGFR) gene mutation is associated with a high rate of distant metastasis and poor prognosis in patients with non-small cell lung cancer (NSCLC). EGFR signaling acts as mediator of bone metastasis by increasing tumor cell proliferation and promotes synthesis and secretion of numerous angiogenic growth factors. We propose that metastatic bone lesions with and without the EGFR mutation in primary NSCLC have different perfusion profiles and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters can reveal the differences.

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