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Abstract #5155

T2-Mapping Relaxation Time Correlates with Histopathological Degree of Degeneration in Meniscal Tissue

Susanne Eijgenraam1, Frans Bovendeert 1, Yvonne Bastiaansen 2, Duncan Meuffels2, Jamal Guenoun 1, Stefan Klein3, Max Reijman2, and Edwin Oei1

1Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, 2Orthopedic Surgery, Erasmus MC, Rotterdam, Netherlands, 3Medical Informatics, Erasmus MC, Rotterdam, Netherlands

To validate meniscal T2-mapping, which is suggested to detect early meniscal degeneration, T2 relaxation times of ten menisci (five traumatically torn and five degenerative menisci from 10 patients) were compared to histopathology as the gold standard to assess meniscal degeneration. T2 relaxation times were found to correlate well with histopathological degree of degeneration in meniscal tissue (rs = 0.64, P = 0.001). Degenerative meniscal tissue was found to exhibit significantly higher T2 relaxation times compared to non-degenerated meniscal tissue (22.7±3.0 ms and 18.2 ±5.1 ms (P = 0.02) respectively). Therefore, T2-mapping is a promising quantitative imaging biomarker for meniscal degeneration.

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