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Abstract #5182

Fat tissue mimics for validation of magnetic resonance thermometry

Slavka Carnicka1, Kathryn Keenan1, Elizabeth Mirowski2, Mark Brown3, Christopher Suiter4, Tara Fortin4, Hannah Erdevig1, Karl Stupic1, and Stephen Russek1

1Physical Measurement Laboratory, National Institute of Standards and Technology, Boulder, CO, United States, 2High Precision Devices Inc., Boulder, CO, United States, 3Department of Radiology, University of Colorado School of Medicine, Denver, CO, United States, 4Applied Chemicals and Materials Division, National Institute of Standards and Technology, Boulder, CO, United States

Phase-based magnetic resonance thermometry is used for monitoring minimally invasive ablation therapies like focused ultrasound therapy. MRT is prone to errors when applied in tissues with high fat content (e.g. breast tissue, fatty liver) due to heat-induced susceptibility changes. Therefore, there is a need for developing well characterized adipose tissue mimics that could serve as standards for validation of MRT techniques. In this study we showed that all measured adipose tissue mimics are representative of human adipose tissue with similar chemical spectra and thermal dependence of susceptibility shift and are reproducible standards for human adipose tissue validation MRI techniques.

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