Abstract #5191

Accurate and reliable fat-water MRI breast density measurements

Jie Ding¹, Patricia A Thompson^2,3, Yi Gao^4,5, Marilyn T Marron⁶, Betsy C Wertheim⁶, Maria I Altbach^6,7, Jean-Philippe Galons^6,7, Denise J Roe^6,8, Fang Wang⁹, Gertraud Maskarinec¹⁰, Cynthia A Thomson⁶, Alison Stopeck^3,11, and Chuan Huang^1,5,12,13

¹Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ²Pathology, Stony Brook Medicine, Stony Brook, NY, United States, ³Cancer Center, Stony Brook Medicine, Stony Brook, NY, United States, ⁴Biomedical Informatics, Stony Brook Medicine, Stony Brook, NY, United States, ⁵Computer Science, Stony Brook University, Stony Brook, NY, United States, ⁶Cancer Center, University of Arizona, Tucson, AZ, United States, ⁷Medical Imaging, University of Arizona, Tucson, AZ, United States, ⁸Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, United States, ⁹Stony Brook Medicine, Stony Brook, NY, United States, ¹⁰Cancer Center, University of Hawaii at Manoa, Honolulu, HI, United States, ¹¹Hematology and Oncology, Stony Brook Medicine, Stony Brook, NY, United States, ¹²Radiology, Stony Brook Medicine, Stony Brook, NY, United States, ¹³Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States

Breast density (BD) is a risk factor for breast cancer, which makes the accurate measurement of BD a priority. Mammography is most widely used for BD determination (MG-BD) but ionizing radiation prohibits its use. BD derived from fat-water decomposition MRI (FWMRI-BD) has been proposed. Here we developed an optimized FWMRI-BD measurement (FraG+W) and compared it to MG-BD and a previous FWMRI-BD measurement (Fra80/90). Both FWMRI-BD measures were strongly correlated with MG-BD and exhibited superior test-retest reliability. The proposed automated FraG+W, which quantifies the entire fibroglandular and water content of the breast, is more accurate and reliable than the previous Fra80/90.

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