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Abstract #5194

Muscular fat fraction using high-resolution imaging – comparison of three T2-based methods and chemical shift-encoded imaging

Lena Trinh1, Pernilla Peterson1, Emelie Lind1, Lars E Olsson1, and Sven Månsson1

1Medical Radiation Physics, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden

The most common method for fat-water separation nowadays is chemical shift-encoded imaging (CSEI). However, when studying fat accumulation in skeletal muscles and high spatial resolution fat fraction (FF) images are desired, CSEI might be challenging due to the increased inter-echo spacing. Here, three alternative methods based on T2-relaxation times, have been explored and compared to CSEI by calculating the muscular fat fraction of ten healthy volunteers. All T2-based methods resulted in qualitatively improved high-resolution FF images compared to CSEI, while a 2-parameter non-linear least square fit showed best quantitative agreement to low resolution CSEI.

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