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Abstract #5209

An in vivo analysis of cerebral cortex organization using a new partial volume method applied to 7T MP2RAGE

Guillaume Bonnier1, Kieran O'Brien2,3, Pascal Sati4, Mario Joao Fartaria5, Jon R Polimeni1, Alexis Roche5,6, Daniel S Reich4, Gunnar Krueger7, and Cristina Granziera1,8

1MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2Center for Advanced Imaging, University of Queensland, Brisbane, Australia, 3Siemens Healthcare Pty Ltd, Brisbane, Australia, 4Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 5Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 6Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 7Siemens Medical Solutions USA, Inc., Malvern, MA, United States, 8Neuroimmunology Unit, Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

We performed an analysis of the cortex organization of 10 healthy subjects using partial volume information. Tissue concentration were estimated using a novel algorithm applied to 7T MP2RAGE high resolution images (0.75mm), and ultra high resolution (0.35mm). We identified 3 distinct layers characterized by presence of WM-like signal (inner layer), only GM (central layer) and GM/CSF partial volume (outer layer).

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