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Abstract #5228

Functional MRI of the auditory cortex: maintaining the steady-state in EPI for silent inter-volume delays with different durations

Manoj Shrestha1, H. Sean Lee1,2, Ulrike Nöth1, and Ralf Deichmann1

1Brain Imaging Center (BIC), Goethe University Frankfurt, Frankfurt am Main, Germany, 2Max Planck Institute for Empirical Aesthetics, Frankfurt am Main, Germany

An fMRI sequence for studying the auditory cortex is proposed, allowing for the insertion of silent delays of variable duration between EPI volumes during which auditory stimuli may be presented. Signal steady state conditions are maintained via spin saturation at fixed time points before each EPI volume. The method was successfully tested in vivo, yielding reliable activation of the primary auditory cortex. Results also show that high saturation efficiency is required to avoid erroneous activation patterns in compartments with long T1 such as cerebrospinal fluid.

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