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Abstract #5239

Improved functional connectivity between the ventromedial prefrontal cortex and amygdala with multi-echo EPI: a resting state analysis

Brice Fernandez1, Laura Leuchs 2, Philipp G. Sämann 2, Michael Czisch2, and Victor I. Spoormaker2

1Applications & Workflow, GE Healthcare, Orsay, France, 2Neuroimaging Unit, Max Planck Institute of Psychiatry, Munich, Germany

EPI suffers from signal loss in the ventromedial prefrontal cortex (vmPFC), a region of special interest in affective neuroscience. Last year, we showed that Multi-echo EPI (MEPI) was performing better than EPI in the vmPFC using a fear conditioning task. In the present work, we used a seed in the vmPFC, derived from the fear conditioning data, for a seed-based analysis on resting-state data collected from the same subjects. We demonstrate that the additional vmPFC cluster extent detected in the fear conditioning task reflects anatomically/functionally relevant activation as it is connected to bilateral amygdala and to the default mode network.

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