EPI suffers from signal loss in the ventromedial prefrontal cortex (vmPFC), a region of special interest in affective neuroscience. Last year, we showed that Multi-echo EPI (MEPI) was performing better than EPI in the vmPFC using a fear conditioning task. In the present work, we used a seed in the vmPFC, derived from the fear conditioning data, for a seed-based analysis on resting-state data collected from the same subjects. We demonstrate that the additional vmPFC cluster extent detected in the fear conditioning task reflects anatomically/functionally relevant activation as it is connected to bilateral amygdala and to the default mode network.
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