Abstract #5271

The neurovascular fingerprint of BOLD bSSFP: the impact of vessel size, orientation and intravascular contribution

Klaus Scheffler^1,2, David Kleinfeld^3,4, Philbert Tsai³, Mario Báez-Yánez¹, and Philipp Ehses¹

¹MPI biol Cybernetics, Tübingen, Germany, ²Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, ³Department of Physics, University of California at San Diego, San Diego, CA, ⁴Section of Neurobiology, University of California, La Jolla, CA

The neurovascular fingerprint of BOLD (blood oxygen level dependent) bSSFP (balanced steady-state free precession) is analyzed by Monte Carlo simulations for different vessel geometries and on a vectorized vessel data set of mouse parietal cortex. The results support that bSSFP yields vascular properties similar to those found with spin echo BOLD, a small intravascular signal contribution except for larger vessels, and a high selectivity to microvessels.

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