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Abstract #5271

The neurovascular fingerprint of BOLD bSSFP: the impact of vessel size, orientation and intravascular contribution

Klaus Scheffler1,2, David Kleinfeld3,4, Philbert Tsai3, Mario Báez-Yánez1, and Philipp Ehses1

1MPI biol Cybernetics, Tübingen, Germany, 2Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, 3Department of Physics, University of California at San Diego, San Diego, CA, 4Section of Neurobiology, University of California, La Jolla, CA

The neurovascular fingerprint of BOLD (blood oxygen level dependent) bSSFP (balanced steady-state free precession) is analyzed by Monte Carlo simulations for different vessel geometries and on a vectorized vessel data set of mouse parietal cortex. The results support that bSSFP yields vascular properties similar to those found with spin echo BOLD, a small intravascular signal contribution except for larger vessels, and a high selectivity to microvessels.

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