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Abstract #5286

Organization and hierarchy of the human brain functional network at rest lead to a chain-like core.

Tommaso Gili1,2, Rossana Mastrandrea3, Andrea Gabrielli4, Fabrizio Piras1,2, Gianfranco Spalletta2,5, and Guido Caldarelli3,4

1Enrico Fermi Center, Rome, Italy, 2Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy, 3Networks Unit, IMT School for Advanced Studies, Lucca, Italy, 4Institute for Complex Systems, CNR, Rome, Italy, 5Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States

The intrinsic functional architecture of the brain and its alterations due to cognitive engagement, ageing and diseases are nodal topics in neuroscience, attracting considerable attention from many disciplines of scientific investigation. Complex network theory offers powerful tools to investigate brain connectivity disclosing the structure of the human brain functional network. Here we put forward a number of methods to investigate the network of brain areas coupled by their functional coordination without introducing exogenous thresholds. In this way we overcame the problem of having a fully connected network and found the intrinsic structure of the functional architecture of the brain.

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