Abstract #5288

Identify the neural basis of vascular dynamic network connectivity with high-field fMRI

Yi He^1,2, Maosen Wang^1,2, Xuming Chen^1,2, and Xin Yu¹

¹High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tuebingen, Tuebingen, Germany

The vascular dynamic network connectivity was detected with the resting-state fMRI in rodent and human brains (abstract: 3115). However, the basis of vascular dynamic connectivity is unclear. Here, the GCaMP6-mediated calcium signal simultaneously detected by fiber optics with fMRI showed slow-freuqncy fluctuation (0.01-0.04Hz) correlated to the single-vessel fMRI signal fluctuation with lead times from 1 to 5 seconds. In addition, the correlation was observed on the slow-frequency oscillation of the power profile of the spontaneous calcium burst spikes with frequency bandwidth of 1-10Hz. Thus, the vascular dynamic network connectivity demonstrates the hemodynamic state changes coupled to the brain state fluctuation.

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