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Abstract #5288

Identify the neural basis of vascular dynamic network connectivity with high-field fMRI

Yi He1,2, Maosen Wang1,2, Xuming Chen1,2, and Xin Yu1

1High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tuebingen, Tuebingen, Germany

The vascular dynamic network connectivity was detected with the resting-state fMRI in rodent and human brains (abstract: 3115). However, the basis of vascular dynamic connectivity is unclear. Here, the GCaMP6-mediated calcium signal simultaneously detected by fiber optics with fMRI showed slow-freuqncy fluctuation (0.01-0.04Hz) correlated to the single-vessel fMRI signal fluctuation with lead times from 1 to 5 seconds. In addition, the correlation was observed on the slow-frequency oscillation of the power profile of the spontaneous calcium burst spikes with frequency bandwidth of 1-10Hz. Thus, the vascular dynamic network connectivity demonstrates the hemodynamic state changes coupled to the brain state fluctuation.

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