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Abstract #5292

Effects of motor dysfunction on functional connectivity and network topology in Parkinson’s disease

Karthik Sreenivasan1, Virendra Mishra1, Zhengshi Yang1, Xiaowei Zhuang1, Sarah Banks1, Dietmar Cordes1,2, and Ryan R Walsh1

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States

The objective of this study was to use resting-state functional connectivity and graph theory to determine how the topology of the network is altered in PD with respect to severity of motor dysfunction. The current study revealed altered functional connectivity and topological properties of networks in PD with respect to severity of motor dysfunction. Our results point to a shift towards a less efficient network topology with altered integration and segregation in more motorically affected patients.

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