Abstract #5294

Subthalamic nucleus activation under audio-motor transformation in lateralized Parkinson’s disease

Oleksii Omelchenko¹, Zinayida Rozhkova², Irina Karaban³, and Mykola Makarchuk⁴

¹Human and Animal Physiology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, ²Medical Clinic BORIS, Kyiv, Ukraine, ³Department of extrapyramidal disorders, D. F. Chebotarev Institute of Herontology, Kyiv, Ukraine, ⁴Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

We hypothesized that audio-motor transformation (AMT) play an important role in voice-guided movement initiation with STN involvement. We propose AMT-related subthalamic nucleus activation analysis in lateralized PD for tremor asymmetry influence study. We identified PD symptoms laterality dependent STN activation peculiarities. Obligatory left STN activation in AMT supposes its role in motor command switching. Bilateral STN activation during the movement execution supports its proposed role as a motor error correction node.

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