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Abstract #5299

Lower Resting Cerebral Blood Flow but Greater Cerebrovascular Reactivity in Young Adults with Higher Aerobic Fitness

Catherine Foster1, Jessica J Steventon1,2, Daniel Helme1, Valentina Tomassini3, and Richard G Wise1

1School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 2School of Medicine, National Mental Health Research Institute, Cardiff, United Kingdom, 3School of Medicine, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff, United Kingdom

We measured the association between aerobic fitness and cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in young, healthy adults using multiple inversion time (MTI) arterial spin labelling (ASL), with a hypercapnic challenge to assess CVR. The results show that higher fitness is associated with lower baseline CBF and greater CVR. Although studies with a larger sample size are required to clarify the relationship between fitness and cerebrovascular function in early adulthood, the current results suggest that aerobic fitness may promote vascular efficiency and reserve.

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