Unlike blood oxygen level dependent (BOLD)-fMRI, accurate physiologic adjustment for subjects during rs-fMRI data acquisition does not seem to be critical for the quality of the final data. In this study, we performed rs-fMRI measurements during normal and abnormal physiological conditions and analyzed betweenness centrality (BC), degree centrality (DC) and eigenvector centrality (EC). In this study, we demonstrate that physiologic conditions seem to have a direct effect on the rs-fMRI result. Thus, the results of our current study suggest that normal physiologic condition should be maintained for rs-fMRI data acquisition.
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