Abstract #5350

Linear and non-linear BOLD effects in grip force execution are reproduced in observation

Letizia Casiraghi^1,2, Adnan AS Alahmadi ^3,4, Karl J Friston ⁵, Claudia AM Gandini Wheeler-Kingshott^6,7,8, and Egidio D'Angelo ^1,2

¹Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ²Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, ³Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, ⁴UCL Institute of Neurology, Queen Square MS center, University College London, London, United Kingdom, ⁵UCL Institute of Neurology, Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ⁶Department of Brain and Behavioral Sciences, University of Pavia, Italy, ⁷UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ⁸Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

In this pilot study, we investigated whether the non-linear BOLD response to varying grip force (GF) is reproduced when observing others performing the task. We used an fMRI squeezeball paradigm with two conditions: action execution (AE - subjects performed the task) and action observation (AO - subjects watched a video of the task). In both conditions, activations were detected in areas constituting the action execution-observation network and both areas evidenced linear and non-linear relations with the GF. These results indicate that action observation calls on the same context sensitive and high level processing necessary for execution.

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