Abstract #5354

Alteration of intrinsic brain activity in children with obstructive sleep apnea syndrome revealed by resting-state functional magnetic resonance imaging

Shuangfeng Yang¹, Shengpei Wang^2,3,4,5, Yue Liu¹, Wenfeng Li¹, Hongbin Li⁶, Jishui Zhang⁷, Yang Fan⁸, Hua Cheng¹, Huiguang He^2,3,4,5, and Yun Peng¹

¹Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, ²The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China, ³Research Center for Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China, ⁴Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, People's Republic of China, ⁵Department of pattern recognition and intelligent system, University of Chinese Academy of Sciences, Beijing, People's Republic of China, ⁶Otolaryngology, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, ⁷Neurology department, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, ⁸MR Research China, GE Healthcare, Beijing, People's Republic of China

Obstructive sleep apnea syndrome (OSAS) in adults has been demonstrated tobe associated with brain functional and structural changes. However, little is known about the changes in regional synchronization of spontaneous brain activity and spontaneous fluctuations in children with OSAS. In the present study, regional homogeneity (ReHo) analysis and amplitude of low-frequency fluctuation (ALFF) based on resting-state functional magnetic resonance imaging (MRI) were used to investigate spontaneous brain activity in children with OSAS compared with controls (CN). As a result, children with OSAS showed significant functional alterations of the cerebellum and temporal gyrus in children with OSAS.

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