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Abstract #5354

Alteration of intrinsic brain activity in children with obstructive sleep apnea syndrome revealed by resting-state functional magnetic resonance imaging

Shuangfeng Yang1, Shengpei Wang2,3,4,5, Yue Liu1, Wenfeng Li1, Hongbin Li6, Jishui Zhang7, Yang Fan8, Hua Cheng1, Huiguang He2,3,4,5, and Yun Peng1

1Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, 2The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China, 3Research Center for Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China, 4Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, People's Republic of China, 5Department of pattern recognition and intelligent system, University of Chinese Academy of Sciences, Beijing, People's Republic of China, 6Otolaryngology, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, 7Neurology department, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China, 8MR Research China, GE Healthcare, Beijing, People's Republic of China

Obstructive sleep apnea syndrome (OSAS) in adults has been demonstrated tobe associated with brain functional and structural changes. However, little is known about the changes in regional synchronization of spontaneous brain activity and spontaneous fluctuations in children with OSAS. In the present study, regional homogeneity (ReHo) analysis and amplitude of low-frequency fluctuation (ALFF) based on resting-state functional magnetic resonance imaging (MRI) were used to investigate spontaneous brain activity in children with OSAS compared with controls (CN). As a result, children with OSAS showed significant functional alterations of the cerebellum and temporal gyrus in children with OSAS.

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