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Abstract #5363

A BOLD analysis of the olfactory perception system in the mouse whole brain, using independent component analysis

Hirotsugu Funatsu1, Fuyu Hayashi1, Sosuke Yoshinaga1, Mitsuhiro Takeda1, Naoya Yuzuriha1, Shunsuke Kusanagi1, and Hiroaki Terasawa1

1Department of Structural BioImaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

A BOLD analysis can trace real-time odor responses at high spatial resolution. Rodents have well-developed olfactory systems, and thus BOLD studies have mainly been performed in rodents. However, mice have smaller brains and are more susceptible to peripheral hemodynamic changes than rats, which make it harder to obtain sufficient BOLD signals. This study revealed the real-time odor response in the mouse whole brain by the BOLD experiment with periodical odor stimulations using a high-sensitivity cryogenic probe and the high-detectability analytical method, Independent Component Analysis (ICA). The signal changes of the activation sites corresponded to the human canonical hemodynamic response function.

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