A BOLD analysis can trace real-time odor responses at high spatial resolution. Rodents have well-developed olfactory systems, and thus BOLD studies have mainly been performed in rodents. However, mice have smaller brains and are more susceptible to peripheral hemodynamic changes than rats, which make it harder to obtain sufficient BOLD signals. This study revealed the real-time odor response in the mouse whole brain by the BOLD experiment with periodical odor stimulations using a high-sensitivity cryogenic probe and the high-detectability analytical method, Independent Component Analysis (ICA). The signal changes of the activation sites corresponded to the human canonical hemodynamic response function.
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