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Abstract #5411

Detecting gamma frequency neural activity using simultaneous multiband EEG-fMRI

Makoto Uji1, Ross Wilson1, Susan T. Francis2, Stephen D. Mayhew1, and Karen J. Mullinger1,2

1Centre for Human Brain Health (CHBH), University of Birmingham, Birmingham, United Kingdom, 2SPMIC, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom

We establish a methodology for optimal combination of simultaneous EEG recording with sparse multiband fMRI that preserves high resolution, whole brain fMRI coverage with broad-band EEG signal measurement uncorrupted by MR gradient artefacts. We demonstrate the ability of this approach to record gamma frequency (>50Hz) EEG signals, that are usually obscured during continuous fMRI data acquisition. In a novel application to a motor task we observe a positive correlation between gamma and BOLD responses, supporting and extending previous findings concerning the coupling between neural and haemodynamic measures of brain activity.

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