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Abstract #5418

Quantitative Evaluation of Thermochemical Ablation Injections in Bovine Liver Phantoms using ²³Na MRI

Tobias Theis1, Nicolas G. R. Behl1, Erik N. K. Cressman2, Armin M. Nagel1,3, Sebastian Flassbeck1, Aaron Kujawa1, Peter Bachert1, Mark E. Ladd1, and Florian Maier1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Thermochemical ablation (TCA), a novel minimally invasive ablation therapy, was quantitatively evaluated using 23Na MRI at 7T. In this study, eight TCA injection experiments were performed using eight ex vivo bovine liver phantoms. Normalization on the reference tubes and B1-correction of the 23Na images were performed to get quantitative values. This improved the maximum relative error of the estimated amount of substance by a factor of 3.6. The total injected amount was accurately determined. This study shows that quantitative 23Na MRI provides detailed information about TCA injections, which is important for computational modelling of the method and cell damage prediction.

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