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Abstract #5431

Detailing radio frequency heating induced release of a fluorescent model drug attached to a thermoresponsive polymer carrier: A 7.0 T thermal MR study

Yiyi Ji1, Alexander E. Dunn2, Michal Pham1, Werner Hoffmann3, Min-Chi Ku1, Helmar Waiczies4, Sonia Waiczies1, Cyrille Boyer2, May Lim2, Thoralf Niendorf1,4,5, and Lukas Winter1

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, 2School of Chemical Engineering, University of New South Wales, Sydney, Australia, 3Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 4MRI.TOOLS GmbH, Berlin, Germany, 5Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz association, Berlin, Germany

Utilizing the RF pulses of the MR system for MR imaging, controlled RF heating and temperature monitoring with MRTh in an integrated system is appealing for MR guided thermal interventions. In this work, we demonstrate for the first time the applicability of our integrated system for targeted drug delivery using a pH- and thermoresponsive polymer. Upon RF heating to T>LCST, the polymers released 50% of its load in 30min, and 89% in 120min. Temperature monitoring with MRTh and external fiber optic temperature sensors were well correlated, with a deviation of 0.2-0.9°C.

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