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Abstract #5476

Absolute quantification of brain metabolites by 1H-MRSI using gradient echo imaging of ~2s as a concentration reference: initial findings

Eva Heckova1, Bernhard Strasser1, Michal Pova┼żan1,2, Gilbert Hangel1, Siegfried Trattnig1,2, and Wolfgang Bogner1,2

1High Field MR Centre, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

The unsuppressed internal water signal is a standard reference method used for quantification of brain metabolites in 1H-MRSI, however it requires additional water unsuppressed acquisition, which is in case of MRSI time demanding. Therefore we compared the performance of water signal reference acquired with unsuppressed MRSI and with ~2s long gradient echo imaging integrated into MRSI sequence. Our findings indicates that gradient echo imaging can be used as a concentration reference for 1H-MRSI.

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