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Abstract #5514

semi-adiabatic SPECIAL-based 1H MRSI at 9.4T: Implementation and preliminary validation in a rat brain

Hyeong-Hun Lee1 and Hyeonjin Kim1,2,3

1Department of Biomedical Sciences, Seoul National University, Seoul, Korea, Republic of, 2Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, 3Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Suwon, Korea, Republic of

Given the issues of chemical shift displacement error, B1 inhomogeneity and short T2 at high field, a semi-adiabatic SPECIAL-based MRSI sequence was implemented at 9.4T, which is equipped with a pair of broad-band hyperbolic secant adiabatic full passage pulses for refocusing, and yet, allows a minimum TE of as short as 4.98 ms. In phantom, the effect of the prolonged minimum TE on the J-evolution of coupled spins is negligible. In a rat brain, preliminary quantitative results are in close agreement with the previous results obtained by using single-voxel MRS.

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