During Magnetic Resonance Imaging-guided High Intensity Focused Ultrasound (MR-HIFU) ablation of breast tumors, localization of the tumor during the treatment procedure is important for proper treatment planning. However, the use of a contrast agent during thermal ablation is preferably avoided for reasons of safety and practicality. We propose an image registration approach using pre-treatment eligibility CE and per-treatment non-CE breast MR scans, acquired with a dedicated mDixon-based tumor localization scan. We demonstrate the feasibility of our method in a volunteer study.
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