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Abstract #5559

Feasibility study for implementing low-field MRI with SPIO nanoparticles for endovascular interventions – An alternative to X-ray guided techniques

Jordy K. van Zandwijk1,2, Frank F.J. Simonis1, Robert H. Geelkerken1,2, Robert Meerwaldt2, Friso G. Heslinga1, and Bennie ten Haken1

1Faculty of Science and Technology, University of Twente, Enschede, Netherlands, 2Vascular Surgery, Medisch Spectrum Twente, Enschede, Netherlands

Low-field magnetic resonance imaging (lf-MRI) using super-paramagnetic iron-oxide (SPIO) nanoparticles as contrast agent seems to be a promising radiation free alternative to guide endovascular interventions in patients with critical limb ischemia (CLI). We propose an innovative workflow on how to deploy lf-MRI during such an intervention and investigate in phantoms the achievable contrast and resolution levels. The results showed that this combination of lf-MRI with SPIO contrast has potential to guide endovascular interventions, but that high quality pre-operative imaging might be required in deployment of this technique.

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