Meeting Banner
Abstract #5581

Peripheral Nerve Stimulation in MRI: Insights from a three level analysis and coupled EM-electrophysiological simulations in neuro-functionalized human models

Antonino Mario Cassara'1, Esra Neufeld1, Gisela Hagberg2, Manuel Guidon3, Klaus Scheffler4, and Niels Kuster1,5

1IT'IS Foundation, Zurich, Switzerland, 2Max Plank Institute - Tuebingen, 3Zurich MedTech, 4Max Plank Institute - Tuebingen, Germany, 5ETH, Zurich, CH

The mechanisms of peripheral nerve stimulation (PNS) induced by the fast switching of MRI gradient coils are only partially understood, stimulation sites and E-field (or dB/dt) thresholds show large inter-subject variability and neurostimulation models based on the amphibian SENN axon model are not ideal. We propose a 3 level computational investigation that combines analysis of E-field exposure, of activation functions, and of multi-parametric EM-electrophysiological simulations in neuro-functionalized human models for different axon models and gradient waveforms. Results concerning E-field/dB/dt thresholds values and sites of neurostimulation are compared with published experimental data. A functional uncertainty analysis is also provided.

This abstract and the presentation materials are available to members only; a login is required.

Join Here