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Abstract #5588

Effect of liver transplantation on muscle metabolism and the abdomen adipose tissue volume in diabetic and non-diabetic patients

Petr Sedivy1, Miloslav Drobny1, Monika Dezortova1, Irena Hejlova2, Monika Cahova3, Pavel Trunecka2, and Milan Hajek1

1MR-unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Hepatogastroenterology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 3Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Liver transplantation (TxL) is a treatment that rapidly improves the clinical status of patients. However, side effects due to long-term immunosuppressive therapy may negatively influence the function of certain organs and metabolism. 31P MRS and MRI are suitable methods for the clinical examination of muscles and abdomen fat volume in transplanted patients. Our pilot results show that TxL leads to an improvement of resting muscle metabolism in especially in diabetic patients and an increase of volume visceral fat in a short term (six months) after transplantation.

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