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Abstract #5590

Online quantification of lactate concentration in microdialysate during cerebral activation using 1H-MRS and sensitive NMR microcoil

Leslie Mazuel1, Ursule Dumont2, Noël Pinaud2, Vanessa Zhendre2, Silvia Rizzitelli2, Jordy Blanc1, Hélène Roumes1, Anne-Karine Bouzier-Sore1, and Yannick Crémillieux2

1CRMSB, Université de Bordeaux, Bordeaux, France, 2Institut des Sciences Moléculaires, Université de Bordeaux, Bordeaux, France

The role of lactate in neuronal activation is central in the hypothesis of the astrocyte-to-neurons lactate shuttle. In this work, we implement highly sensitive 1H-MRS on brain microdialysate in order to monitor online the lactate fluctuations during neuronal activation in the S1BF area. The custom-made microcoil used in this study was shown to be sensitive enough for measuring a 40% increase in lactate concentration during brain stimulation.

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