Abstract #5590

Online quantification of lactate concentration in microdialysate during cerebral activation using 1H-MRS and sensitive NMR microcoil

Leslie Mazuel¹, Ursule Dumont², Noël Pinaud², Vanessa Zhendre², Silvia Rizzitelli², Jordy Blanc¹, Hélène Roumes¹, Anne-Karine Bouzier-Sore¹, and Yannick Crémillieux²

¹CRMSB, Université de Bordeaux, Bordeaux, France, ²Institut des Sciences Moléculaires, Université de Bordeaux, Bordeaux, France

The role of lactate in neuronal activation is central in the hypothesis of the astrocyte-to-neurons lactate shuttle. In this work, we implement highly sensitive 1H-MRS on brain microdialysate in order to monitor online the lactate fluctuations during neuronal activation in the S1BF area. The custom-made microcoil used in this study was shown to be sensitive enough for measuring a 40% increase in lactate concentration during brain stimulation.

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