Abstract #5592

Characterization of Water Compartment Exchange in Ex-Vivo Human Cartilage Using Two-Dimensional Relaxometry

Kyle William Sexton¹, David A. Reiter¹, Hasan Celik², Kenneth Fishbein¹, Tariq Nayfeh³, and Richard G. Spencer¹

¹Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, Baltimore, MD, United States, ²University of California, Berkeley, CA, United States, ³Medstar Harbor Hospital, Baltimore, MD, United States

One-dimensional transverse relaxometry has proven to be an effective method for characterizing macromolecular compartments in cartilage. Two-dimensional studies extend the capabilities of these types of experiments, providing characterization of tissue compartments in terms of correlated relaxation times and providing a means of probing intercompartmental exchange. We provide results of T₂-T₂ and T₁-T₂ relaxometry experiments on human articular cartilage, indicating that exchange between tissue compartments may be augmented in degraded tissue.

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