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Abstract #5592

Characterization of Water Compartment Exchange in Ex-Vivo Human Cartilage Using Two-Dimensional Relaxometry

Kyle William Sexton1, David A. Reiter1, Hasan Celik2, Kenneth Fishbein1, Tariq Nayfeh3, and Richard G. Spencer1

1Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, Baltimore, MD, United States, 2University of California, Berkeley, CA, United States, 3Medstar Harbor Hospital, Baltimore, MD, United States

One-dimensional transverse relaxometry has proven to be an effective method for characterizing macromolecular compartments in cartilage. Two-dimensional studies extend the capabilities of these types of experiments, providing characterization of tissue compartments in terms of correlated relaxation times and providing a means of probing intercompartmental exchange. We provide results of T2-T2 and T1-T2 relaxometry experiments on human articular cartilage, indicating that exchange between tissue compartments may be augmented in degraded tissue.

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