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Abstract #5604

Comprehensive Metabolic Profiling of Urosepsis with positive and negative controls

Suruchi Singh1, Tanushri Chatterji2, Manodeep Sen2, Ishwar Ram Dhayal3, and Raja Roy1

1Centre of Biomedical Research, Lucknow, India, 2Department of Microbiology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India, 3Department of Urology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India

This study presents the metabolic perturbation in serum and urine samples while comparing Urosepsis with negative and positive controls. It explores the metabolic differentiation of serum samples with sepsis and urine samples with urinary tract infection (UTI) (considered as positive controls), and healthy controls (considered as negative controls) respectively. The serum and urine metabolic profile mainly depicted changes occurring due to severity and spread of infection. The statistical Partial Least Square Discriminant Analysis (PLS-DA) model was robust enough to differentiate the three groups distinctively in both serum and urine samples.

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