31P MRS of the brain can reveal changes in energy and lipid metabolism in healthy and diseased brain. In this abstract we compare 31P MRS measurements with and without NOE and/or 1H-decoupling. Adding nuclear Overhauser enhancement (NOE) and 1H-decoupling to a 31P MRS measurement at 3T increases spectral resolution to that at 7T and improves sensitivity so that the theoretical difference with 7T is partly compensated for. At relatively short repetition times both 1H-decoupling and NOE have to be taken into account for proper quantification.
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