Abstract #5616

Short TE PRESS-based proton observed carbon edited (POCE) 13C Magnetic Resonance Spectroscopy with a volumetric 1H transmitter for in vivo rat brain imaging at 7T

Chathura Kumaragamage^1,2, Dan Madularu^2,3, Axel Mathieu^2,3, Henk De Feyter⁴, Natasha Rajah^2,3, and Jamie Near^1,2,3

¹Biomedical Engineering, McGill University, Montreal, QC, Canada, ²Brain Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada, ³Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Carbon-13 (13C) magnetic resonance spectroscopy (MRS) remains to be the only noninvasive method capable of measuring neuroenergetics and neurotransmitter cycling in the brain in vivo [1]. However, 13C MRS is a challenging technique to implement, and suffers from low sensitivity. In this study we investigated a short TE (12.6 ms) PRESS localized proton observed carbon edited 13C MRS utilizing a volumetric resonator for proton excitation. The designed platform demonstrates high sensitivity to 1H signals, provides excellent localization, and high resolution 1H and 1H-[13C] spectra for in vivo rat brain imaging.

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