Meeting Banner
Abstract #5616

Short TE PRESS-based proton observed carbon edited (POCE) 13C Magnetic Resonance Spectroscopy with a volumetric 1H transmitter for in vivo rat brain imaging at 7T

Chathura Kumaragamage1,2, Dan Madularu2,3, Axel Mathieu2,3, Henk De Feyter4, Natasha Rajah2,3, and Jamie Near1,2,3

1Biomedical Engineering, McGill University, Montreal, QC, Canada, 2Brain Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada, 3Department of Psychiatry, McGill University, Montreal, QC, Canada, 4Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Carbon-13 (13C) magnetic resonance spectroscopy (MRS) remains to be the only noninvasive method capable of measuring neuroenergetics and neurotransmitter cycling in the brain in vivo [1]. However, 13C MRS is a challenging technique to implement, and suffers from low sensitivity. In this study we investigated a short TE (12.6 ms) PRESS localized proton observed carbon edited 13C MRS utilizing a volumetric resonator for proton excitation. The designed platform demonstrates high sensitivity to 1H signals, provides excellent localization, and high resolution 1H and 1H-[13C] spectra for in vivo rat brain imaging.

This abstract and the presentation materials are available to members only; a login is required.

Join Here