Meeting Banner
Abstract #5628

Realistic simulation of 23Na brain data: Understanding the influence of acquisition parameters on the accuracy of 23Na concentration measurement

Jonathan M. Lommen1, Nicolas G.R. Behl1, Peter Bachert1, Mark E. Ladd1, and Armin M. Nagel1,2

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Sodium (23Na) is connected to tissue physiology and can be spatially resolved by MRI. Low in-vivo concentrations and short relaxation times render a quantitative determination challenging. We present a simulation method which allows synthesizing realistic 23Na MRI raw data. Thereby, most effects in typical quantification experiments on the basis of an external concentration reference can be studied. To establish a reference accuracy level, we investigate the influence of T2* decay, undersampling, TE, and TR on 23Na quantification. The presented simulations can be used for the testing and evaluation of quantitative reconstruction methods as well as to test significance in clinical studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here