Abstract #5630

Investigation of Strophanthin Induced Na-/K-ATPase Blockage by Means of 23Na Multi Quantum Spectroscopy in a High Density Cell Culture on Chip

Andreas Neubauer¹, Matthias Malzacher¹, Victor Schepkin², Jorge Chacon-Caldera¹, Ruomin Hu¹, Eric Gottwald³, Cordula Nies³, David Thiele³, and Lothar Schad¹

¹Computer Assisted Clinical Medicine/CBTM, Heidelberg University, Mannheim, Germany, ²CIMAR, National High Magnetic Field Laboratory/FSU, Tallahassee, FL, United States, ³Institute for Biological Interfaces-5, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany

Sodium multi quantum (MQ) spectroscopy was used to record single (SQ) and triple quantum (TQ) resonances from a 3D cell culture implanted in a MRI compatible bioreactor under the strophanthin induced inhibition of the sodium-potassium pump (Na-/K-ATPase) at 9.4T. The results show a clear alteration in the ratio TQ/SQ under strophanthin influence. Due to the high control of physiological parameters the bioreactor provides, this alteration can be directly linked to the inhibition of the Na-/K-ATPase.

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