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Abstract #5639

Mapping brain macromolecules in patients with multiple sclerosis using 1H-MRSI at 7T

Michal Považan1,2, Eva Heckova1, Gilbert Hangel1, Bernhard Strasser1, Stephan Gruber1, Assunta Dal-Bianco3, Fritz Leutmezer3, Siegfried Trattnig1,2, and Wolfgang Bogner1,2

1Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Neurology, Medical University Vienna, Vienna, Austria

Multiple sclerosis (MS) is a disease of the central nervous system associated with demyelination and glial activation affecting large areas of white matter. 1H-MRSI may detect the metabolic changes induced by MS and facilitate the differentiation between MS lesions. Our study aimed to detect and map the signal of macromolecules in healthy controls and MS patients. 2D FID-based 1H-MRSI was used with measurement time under 6 minutes. We found increased macromolecules in the perilesional region and decreased macromolecules in most of the lesions. However, in some lesions, macromolecules were increased, which may be possibly related to pathological activation of lesion.

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