Abstract #5639

Mapping brain macromolecules in patients with multiple sclerosis using 1H-MRSI at 7T

Michal Považan^1,2, Eva Heckova¹, Gilbert Hangel¹, Bernhard Strasser¹, Stephan Gruber¹, Assunta Dal-Bianco³, Fritz Leutmezer³, Siegfried Trattnig^1,2, and Wolfgang Bogner^1,2

¹Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Department of Neurology, Medical University Vienna, Vienna, Austria

Multiple sclerosis (MS) is a disease of the central nervous system associated with demyelination and glial activation affecting large areas of white matter. ¹H-MRSI may detect the metabolic changes induced by MS and facilitate the differentiation between MS lesions. Our study aimed to detect and map the signal of macromolecules in healthy controls and MS patients. 2D FID-based ¹H-MRSI was used with measurement time under 6 minutes. We found increased macromolecules in the perilesional region and decreased macromolecules in most of the lesions. However, in some lesions, macromolecules were increased, which may be possibly related to pathological activation of lesion.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.