Abstract #5639

Mapping brain macromolecules in patients with multiple sclerosis using 1H-MRSI at 7T

Michal Považan^1,2, Eva Heckova¹, Gilbert Hangel¹, Bernhard Strasser¹, Stephan Gruber¹, Assunta Dal-Bianco³, Fritz Leutmezer³, Siegfried Trattnig^1,2, and Wolfgang Bogner^1,2

¹Department of Biomedical Imaging and Image-guided Therapy, High Field MR Centre, Medical University Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Department of Neurology, Medical University Vienna, Vienna, Austria

Multiple sclerosis (MS) is a disease of the central nervous system associated with demyelination and glial activation affecting large areas of white matter. ¹H-MRSI may detect the metabolic changes induced by MS and facilitate the differentiation between MS lesions. Our study aimed to detect and map the signal of macromolecules in healthy controls and MS patients. 2D FID-based ¹H-MRSI was used with measurement time under 6 minutes. We found increased macromolecules in the perilesional region and decreased macromolecules in most of the lesions. However, in some lesions, macromolecules were increased, which may be possibly related to pathological activation of lesion.

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