Conventional localized 1H MRS pulse sequences, such as PRESS and STEAM, generally suffer from J coupling modulations which can aggravate attenuation of multiplet resonances during echo times. Here, the “perfect echo” module combined with an optimized localization scheme is utilized for in-phase single-voxel in vivo MRS at 9.4 T. The relative signal intensities of multiplet to singlet resonances acquired at short and moderate echo times increase substantially in comparison with those at PRESS spectra. Therefore, direct MRS quantification of many important metabolites, such as glutamine, glutamate, γ-aminobutyrate, aspartate, and myo-inositol, may be improved.
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