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Abstract #5644

Improving the detection of scalar-coupled resonances at short and moderate echo times for in vivo rat MRS at 9.4 T

Liangjie Lin1,2,3, Yanqin Lin1, Dan Tian1, Hongyi Yang4, Zhiliang Wei2,3, Peter B. Barker2,3, Kai Zhong4, and Zhong Chen1

1Department of Electronic Sciense, Xiamen University, Xiamen, People's Republic of China, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 3F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4High Magnetic Field Laboratory, CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Hefei, People's Republic of China

Conventional localized 1H MRS pulse sequences, such as PRESS and STEAM, generally suffer from J coupling modulations which can aggravate attenuation of multiplet resonances during echo times. Here, the “perfect echo” module combined with an optimized localization scheme is utilized for in-phase single-voxel in vivo MRS at 9.4 T. The relative signal intensities of multiplet to singlet resonances acquired at short and moderate echo times increase substantially in comparison with those at PRESS spectra. Therefore, direct MRS quantification of many important metabolites, such as glutamine, glutamate, γ-aminobutyrate, aspartate, and myo-inositol, may be improved.

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