Abstract #0007

Impact of field strength (1.5, 3.0 and 7.0 Tesla) and sequence on quantification of aortic flow volumes, peak velocity and wall shear stress using 4D flow MRI

Stephanie Funk^1,2, Sebastian Schmitter³, Marcel Prothmann¹, Carsten Schwenke⁴, Florian von Knobelsdorff-Brenkenhoff^1,5, Andreas Greiser⁶, Emilie Bollache⁷, Michael Markl⁷, and Jeanette Schulz-Menger^1,2

¹Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine and HELIOS Hospital Berlin Buch, Department of Cardiology and Nephrology, Berlin, Germany, ²DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany, ³Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, ⁴SCO:SSIS Statistical Consulting, Berlin, Germany, ⁵Clinic Agatharied, Department of Cardiology, Ludwig-Maximilians-University Munich, Hausham, Germany, ⁶Siemens Healthcare, Erlangen, Germany, ⁷Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States

For implementing 4D flow in clinical routine, standardization is important. We evaluated equivalence of 4D flow parameters in different sequences and at three different field strengths. Ten healthy volunteers were scanned at 1.5T, 3.0T and 7.0T. At 1.5T, three different sequences were applied. Ascending aorta, aortic arch and descending aorta of each scan were evaluated for diagnostic quality. After exclusion of non-diagnostic segments, equivalence testing for flow, wall shear stress and peak velocity was performed. Acceptable equivalence was determined by intra-rater analysis. Comparison of different field strengths as well as different sequences did not reach equivalence. 4D flow sequences are not interchangeable.

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