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Abstract #0009

Quantitative MRI detects acute vascular effects of e-cig aerosol inhalation

Michael C Langham1, Alessandra Stella Caporale2, and Felix W Wehrli3

13400 Spruce St, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3University of Pennsylvania, Philadelphia, PA, United States

The rapid rise in the popularity and use of the electronic cigarettes among adolescents are unsettling trends in spite of the limited science that exists on the health effects of e-cigarettes. The purpose of this project was to introduce a noninvasive method for the study of the systemic acute effects of e-cigarette aerosol inhalation on the cardiovascular system by means of quantitative MRI that targets various vascular territories. Preliminary data show reduced femoral vein SvO2 and impaired flow-mediated dilation in the femoral artery, along with elevated aortic arch pulse-wave velocity after an e-cigarette challenge equivalent to one conventional cigarette.

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