The rapid rise in the popularity and use of the electronic cigarettes among adolescents are unsettling trends in spite of the limited science that exists on the health effects of e-cigarettes. The purpose of this project was to introduce a noninvasive method for the study of the systemic acute effects of e-cigarette aerosol inhalation on the cardiovascular system by means of quantitative MRI that targets various vascular territories. Preliminary data show reduced femoral vein SvO2 and impaired flow-mediated dilation in the femoral artery, along with elevated aortic arch pulse-wave velocity after an e-cigarette challenge equivalent to one conventional cigarette.
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