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Abstract #0051

The dynamic BOLD-CBF coupling during resting-state in the aging brain: a dual-echo pCASL study

Piero Chiacchiaretta1 and Antonio Ferretti1

1Neuroscience, Imaging and Clinical Sciences, Department of Neuroscience, Imaging and Clinical Sciences - Institute for Advanced Biomedical Technologies, Chieti, Italy

Simultaneous acquisition of BOLD and CBF data using ASL allows the study of resting-state brain function from a different perspective with respect to functional connectivity. In particular, recent evidence showed that spontaneous BOLD and CBF fluctuations are strongly coupled in the cortex. Here we show that this coupling is markedly reduced in elderlies with normal cognitive scores, with a regional specific effect in the left supramarginal gyrus, an area known to be involved in different memory functions. These findings suggest that the study of dynamic BOLD-CBF coupling can potentially offer early biomarkers of functional changes in the aging brain.

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