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Abstract #0053

Influence of end-tidal CO2 on cerebrovascular reactivity mapping: within-subject and across-subject effects

Jill Britt De Vis1, Xirui Hou1, Peiying Liu1, Zheyu Wang2, Siyuan Cheng2, Yang Li1, Harshan Ravi3, and Hanzhang Lu1

1Division of MR Research, Johns Hopkins University, Baltimore, MD, United States, 2Johns Hopkins University, Baltimore, MD, United States, 3National Institutes of Health, Bethesda, MD, United States

The relationship between end-tidal (Et) CO2, and the output measure, BOLD signal, is highly non-linear, due to both physiological non-linearity between cerebral blood flow (CBF) and CO2 as well as biophysical non-linearity between CBF and BOLD. In this study, we found that, across subjects, baseline EtCO2 and ΔEtCO2 inversely influenced the measured CVR values. Therefore, these factors should be taken into account when comparing CVR between groups or patients. However, these inter-subject differences appear to have an independent physiological underpinning, as manipulations of these factors within the subject did not seem to have an effect on the measured CVR values.

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