Imaging protocols that allow diverse contrast mechanisms to be sampled with different mixes open up exciting opportunities for joint modelling of tissue properties. However joint sampling with conventional sequence structures can be extremely inefficient and so prohibitively time consuming. Here we explore the joint inversion recovery-diffusion sampling challenge and create an efficient capability by breaking the “one-volume – one encoding” paradigm to interleave the diffusion encoding not per volume but for every slice. Flexible sampling during inversion recovery allowing sufficient samples for a joint fit to be acquired in a much shorter time. The approach has been tested in normal volunteer brain examinations.
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