Abstract #0091

The relevance of cortical lesions in cortical thinning in multiple sclerosis by ultra-high field MRI

Constantina Andrada Treaba^1,2, Elena Herranz^1,2, Russell Ouellette IV¹, Tobias Granberg^1,2,3,4, Celine Louapre^1,2, Valeria Barletta^1,2, Ambica Mehndiratta¹, Jacob A Sloane^2,5, Revere Kinkel⁶, and Caterina Mainero^1,2

¹Department of Radiology, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Radiology, Karolinska University Hospital, Stockholm, Sweden, ⁵Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States, ⁶Department of Neurosciences, University of California, San Diego, CA, United States

Cortical lesions (CL) and cortical atrophy are frequent in multiple sclerosis (MS) and main determinants of disease progression. The relationship between them is still unknown, mostly due to the low sensitivity of clinical magnetic resonance imaging (MRI) to CL. Disconnection from white matter (WM) lesions has also been proposed as a pathogenic mechanism for cortical MS atrophy. Using 7 Tesla MRI that has shown increased sensitivity to CL than clinical MRI, we showed, in a large MS cohort that WM lesions are the main determinant of cortical thinning. Nevertheless, CL resulted as the main contributors of physical and cognitive disability.

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