Abstract #0112

Brown Adipose Tissue Mass Measurement by Z-Spectrum Imaging

Alessandro M Scotti^1,2,3, Rongwen Tain^1,3, Weiguo Li^1,4,5, Victoria Gil⁶, Chong Wee Liew⁶, and Kejia Cai^1,3

¹Radiology, University of Illinois, Chicago, IL, United States, ²Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ⁴Research Resource Center, University of Illinois at Chicago, Chicago, IL, United States, ⁵Radiology, Northwestern University, Chicago, IL, United States, ⁶Physiology and Biophysics, University of Illinois, Chicago, IL, United States

Brown adipose tissue (BAT) has a great relevance in metabolic diseases and has been shown to be reduced in obesity and insulin resistance patients. Currently, Dixon MRI is used to calculate fat-water fraction (FWF) and differentiate BAT from the less hydrated and more lipid-rich white fat. However, it may introduce fat-water swapping artifacts. Here, we showed that Z-Spectrum MRI can effectively measure FWF and BAT mass in vivo free from artifacts, due to the direct saturation of both water and fat protons.

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