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Abstract #0118

Online Super-resolution 4D T2-weighted MRI for MRI-guided Radiotherapy

Joshua Nathan Freedman1,2, David John Collins2, Oliver Jacob Gurney-Champion1, Simeon Nill1, Uwe Oelfke1, Martin Osmund Leach2, and Andreas Wetscherek1

1Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, 2CR-UK Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

To assist treatment delivery to moving tissues on hybrid MRI-guided radiotherapy systems, high quality midposition (of the respiratory cycle) and 4D-T2w images are desirable. Current approaches to rapidly obtaining 4D-T2w MRI are often limited by thick slices, incomplete motion information and binning artefacts. Midposition and 4D-T2w images were calculated using motion-modelling and a super-resolution reconstruction, and verified by comparison with the initially acquired images. Calculated 4D-T2w images exhibited high spatiotemporal resolution (1.0x1.0x1.0 mm3, 8 respiratory phases), displayed reduced binning artefacts and no missing data. An acquisition time of 5.0-7.5 minutes was found sufficient to obtain representative midposition T2w images.

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