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Abstract #0120

Visual pathway structure and localisation of tumour-induced disturbance in optic pathway glioma: correlations between diffusion-MRI, visual evoked potentials, and optical coherence tomography

Patrick W Hales1, Sian Handley2, Alki Liasis2, Darren Hargrave3, and Chris Clark1

1UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, 2Opthalmology Department, Great Ormond Street Children’s Hospital, London, United Kingdom, 3Haematology and Oncology Department, Great Ormond Street Children’s Hospital, London, United Kingdom

Optic pathway glioma (OPG) is a childhood tumour of the visual pathway. Clinical management of OPG remains challenging, as the extent of tumour infiltration of the visual pathway is not perceptible on conventional MRI. We used diffusion-MRI to delineate the visual pathway in OPG patients. Advanced ophthalmological assessment was also performed using visual evoked potentials (VEP) and optical coherence tomography. We demonstrate that fractional anisotropy (FA) in the optic pathway correlates with retinal nerve-fibre layer thickness and VEP response, and tumour invasion anterior to the optic chiasm can be detected via inter-ocular differences in optic nerve FA.

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