Meeting Banner
Abstract #0136

Neurite Orientation Dispersion and Density Imaging: Added Value in the Detection of Tubers in Patients With Tuberous Sclerosis Complex

Xiali Shao1, Xuewei Zhang2, Wenrui Xu1, Hua Guo3, Zhe Zhang3, Jieying Zhang3, Tao Jiang4, and Weihong Zhang1

1Department of radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, 2Department of interventional radiology, China Meitan General Hospital, Beijing, China, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 4Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing, China

The aim of this study was to evaluate the performance of Neurite Orientation Dispersion and Density Imaging (NODDI) in depicting cortical tubers in patients with tuberous sclerosis complex (TSC). By comparing with conventional MRI and DTI, the intracellular volume fraction (ICVF) derived from NODDI showed privilege over both techniques with higher sensitivity and better contrast ratio. Our result has revealed that NODDI was better at detecting microstructural disruption than DTI and conventional MRI sequences with a more reasonable model assumption, and may somehow shed light on the management of epilepsy in TSC patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here