Abstract #0136

Neurite Orientation Dispersion and Density Imaging: Added Value in the Detection of Tubers in Patients With Tuberous Sclerosis Complex

Xiali Shao¹, Xuewei Zhang², Wenrui Xu¹, Hua Guo³, Zhe Zhang³, Jieying Zhang³, Tao Jiang⁴, and Weihong Zhang¹

¹Department of radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, ²Department of interventional radiology, China Meitan General Hospital, Beijing, China, ³Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ⁴Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing, China

The aim of this study was to evaluate the performance of Neurite Orientation Dispersion and Density Imaging (NODDI) in depicting cortical tubers in patients with tuberous sclerosis complex (TSC). By comparing with conventional MRI and DTI, the intracellular volume fraction (ICVF) derived from NODDI showed privilege over both techniques with higher sensitivity and better contrast ratio. Our result has revealed that NODDI was better at detecting microstructural disruption than DTI and conventional MRI sequences with a more reasonable model assumption, and may somehow shed light on the management of epilepsy in TSC patients.

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